一. 教育经历

   2004.9—2008.7 新奥门31999, 化学化工学院, 本科, 学士学位

   2008.9—2011.7 厦门大学, 化学化工学院, 硕士, 硕士学位,导师:黄培强 教授

   2011.8—2015.9 荷兰代尔夫特理工大学 (Delft University of Technology), 生物工程学院,  博士, 博士学位,导师:Prof. Ulf Hanefeld

二. 工作经历

    2018.10 - 至今 新奥门31999 新奥门31999 副教授 博士研究生导师

    2015.10-2018.10 新奥门31999 新奥门31999 特聘副研究员

三.研究方向

海洋复杂环境及其压力、盐分、温度和营养成分上的多重变化,赋予了海洋微生物在物种资源、基因功能和蛋白特性上的多样性和特殊性。因此,海洋是地球上最大的资源宝库,蕴含丰富的新颖基因和蛋白质宝库,是天然的酶筛选平台,也成为了国际间海洋生物技术竞争的重要领域。因此本人的研究方向聚焦海洋生物酶资源挖掘及其优化和应用,为促进国家海洋生物经济(生物制造)发展提供基础。

四.主持项目

1、国家自然科学基金面上项目 (2024-2026): 51万

2、广东省自然科学基金青年提升项目(2023-2025):30万

3、企业委托项目(2024-2029):100万

4、企业委托项目(2024):5万

5、新奥门31999青年突破项目(2022):30 万

6、广东省自然科学基金面上项目(2020-2022):10 万

7、高校基本科研业务费新奥门31999青年教师培育项目(2017-2019):15万

8、广东省自然科学基金博士启动项目 (2017-2019):10万

9、国家自然科学基金青年基金项目 (2018-2020): 25万

五.授权专利

1. 陈碧双,曾咏仪,刘岚,一种光脱羧酶或其重组酶的应用及一种重组光脱羧酶,2023,专利号:ZL 202210272621.X,授权日:2023.11.03

2. 陈碧双,张迪,刘岚,一种产淀粉酶的菌株,2023,专利号:ZL 202210353873.5,授权日:2023.11.03

3. 陈碧双,刘岚,刘慧,杨振男,白地霉菌株不对称催化还原卤代芳香酮的方法,2020,专利号:ZL 201710511310.3, 授权日:2020.04.07

4. 陈碧双,刘岚,刘慧,杨振男,一种烯键还原酶及其制备方法和应用,2019,专利号:ZL201710101780.2,授权日:2019.11.26

5. 陈碧双 、刘岚 、刘慧,(S)-选择性生物催化剂,2019,专利号:ZL 201810446596.6,授权日:2019.08.09

6. 陈碧双 、刘岚 、刘慧,一株海洋来源聚多曲霉及其用途,2019,专利号:ZL 201810446807.6,授权日:2019.07.23

 

六.教学工作

(1)教学课程

    本科生:专业必修课程《分析化学》、野外实践教学(综合实习)

研究生:专业硕士核心课程《资源与环境》、选修课程《海洋微生物催化与转化》及《海洋有机化学与现代测试技术》

(2)教改项目

广东省本科高校教学质量与教学改革工程项目高等教育教学改革项目(2024.01-2026.07)

(3)教学奖励

新奥门31999第十届教师教学竞赛理科组二等奖(2022)

(4)教学论文

陈碧双,高志增,李静,陈森华,刘岚. 海洋化学野外实习课程教学改革与实践,《实验室研究与探索》(北大核心期刊,IF=1.7),2023, 42, 231-236,DOI:10.19927/j.cnki.syyt.2023.08.047

(5)课程思政

     获“海洋强国,思政领航”全国海洋科学类专业课程思政教学研讨会优秀案例二等奖(2023)

(6)学生工作

     2024 年度新奥门31999优秀辅导员

 

七. 以第一作者/通讯作者发表的期刊论文

21. Xinjian Yin, Wenzhong Gong, Yujing Zeng, Hulin Qiu, Lan Liu, Frank Hollmann,* and Bishuang Chen*,Substrate-speciffc evolution of amine dehydrogenases for accessing structurally diverse enantiopure (R)‑β-amino alcohols,ACS Catalysis, 2024, 14, 837−845

20. Yong-Yi Zeng, Xin-Yi Xu, Jin-Xuan Xie, Wen-Li Che, Lan Li, Xin-Jian Yin*, Bi-Shuang Chen*. Lipase and photodecarboxylase co-expression: a potential strategy for alkane-based biodiesel production from natural triglycerides. Chinese Journal of Chemical Engineering, (2024) 67, 238-246.

19. Yalan Zhang, Xiaoying Zhou, Jiandong Cui, Yawen Huang, Xiaoxiao Liu, Yunhan Zhang, Bishuang Chen*, Wuyuan Zhang*, Peroxygenase-catalysed selective and scalable synthesis of 25-hydroxy-grundmann’s ketone and its derivatives. Molecular Catalysis 547 (2023) 11338.

18. Di Zhang, Lan Liu, Bi-Shuang Chen*, Marine-derived fungi as a valuable resource for amylases activity screening. J. Fungi 2023, 9, 736. https://doi.org/10.3390/jof9070736.

17. Yong-Yi Zeng, Xinjian Yin, Lan Liu, Wuyuan Zhang, Bishuang Chen*. Comparative characterization and physiological function of putative fatty acid photodecarboxylases. Molecular Catalysis, 2022, 532:112717.

16. Bi-Shuang Chen, Di Zhang, Fayene Zeferino Ribeiro de Souza,* Lan Liu. Recent advances in the synthesis of marine-derived alkaloids via enzymatic reactions. Marine Drugs, 2022, 20:368.

15. Bi-Shuang Chen, Yong-Yi Zeng, Lan Liu, Lei Chen, Peigao Duan, Rafael Luque, Ran Ge, Wuyuan Zhang. Renewable and Sustainable Energy Reviews, 2022, 158:112178.

14. Yong-Yi Zeng, Lan Liu, Bi-Shuang Chen*, Wuyuan Zhang. Light-driven enzymatic decarboxylation of dicarboxylic acids. ChemistryOpen, 2021, 10:553.

13. Chen Bi-Shuang, de Souza FZR, Enzymatic synthesis of enantiopure alcohols: current state and perspectives. RSC Advances, 2019,9, 2102-2115 

12. Chen Bi-Shuang#, Médici R#, van der Helm MP, van Zwet Y, Gjonaj L, van Der Geest R, OttenLG, Hanefeld U (2018) Rhodococcus strains as source for ene-reductase activity. Applied Microbiology and Biotechnology,102:5545-5556.

11. Liu H, de Souza FZR, Liu L*, Chen Bi-Shuang*, (2018) Immobilized and free cells of Geotrichum candidum for asymmetric reduction of ketones: stability and recyclability. Molecules, 2018, 23: 2144-2168.

10. Liu H,  Duan W-D, de Souza FZR, Liu L, Chen Bi-Shuang*, (2018) Asymmetric Ketone Reductionby Immobilized Rhodotorula Mucilaginosa. Catalysts, 8, 165; doi:10.3390/catal8040165.

9. Liu H, Chen Bi-Shuang*, de Souza FZR, Liu L (2018) A Comparative Study on Asymmetric Reduction of Ketones Using the Growing and Resting Cells of Marine-Derived Fungi. Marine Drugs 16:62.

8. Liu H, de Souza FZR, Liu L, Chen Bi-Shuang*, (2018) The use of marine-derived fungi for preparation of enantiomerically pure alcohols. Applied Microbiology and Biotechnology 102:1317–1330.

7. Li F, Lin Z-F, Wen J-S, Wei Y-S, Gan H-Y, He H-J, Lin J-Q, Xia Z, Chen Bi-Shuang*, Guo W-J, Tan C-S, Cai H-Y. (2017). Risk assessment of trace metal-polluted coastal sediments on Hainan Island: A fullscale set of 474 geographical locations covering the entire island. Marine Pollution Bulletin, 125:541-555.

6. Chen Bi-Shuang, Liu H, deSouza FZR, Liu L (2017). Organic solvent-tolerant marine microorganisms as catalystsfor kinetic resolution of cyclic β-hydroxyk ketones. Marine Biotechnology, 19:351-360.

5. Chen Bi-Shuang, Otten LG,Hanefeld U (2015) Stereochemistry of enzymatic water addition to C = C bonds, Biotechnology Advances 33: 526-546.

4. Chen Bi-Shuang, Resch V, Otten, LG, Hanefeld U (2015) Enantioselective Michael addition of water, Chemistry-A European Journal 21: 3020-3030.

3. Chen Bi-Shuang, Hanefeld U (2013) Enantioselective preparation of (R)- and(S)-3-hydroxycyclopentanone by kinetic resolution, Journal of MolecularCatalysis B: Enzymatic 85: 239-242.

2. Chen Bi-Shuang, Otten LG,Resch V,  Muyzer G, Hanefeld U (2013)Draft genome sequence of Rhodococcus rhodochrous ATCC 17895, Standards in GenomicSciences 9: 175-184.

1. Chen Bi-Shuang, Yang L-H, Ye J-L,Huang T, Ruan Y-P, Fu J, Huang P-Q (2011) Diastereoselective synthesis andbioactivity of long-chain anti-2-amino-3-alkanols, European Journal ofMedicinal Chemistry 46: 5480-5486.