招生专业

海洋生物学

个人详细介绍

     教授，博士生导师，主要研究方向为海洋鱼类细胞系建立及应用、海洋病毒与宿主互作机制和免疫防控技术、抗病毒药物筛选和药效评估、海洋噬菌体功能基因挖掘及利用. 围绕重要海水鱼类病毒致病机制和防控技术开展系统性研究， 近年来，以第一/通讯作者（包括共同第一作者和通讯作者）在PLoS Pathogens， Journal of Virology， Journal of Immunology， Frontiers in Immunology和Aquaculture等国内外重要刊物发表论文60余篇。主持国家、省市级科研项目10项，地方服务项目4项。担任国际期刊water编委，Stem Cells，iScience， Science of the Total Environment及《渔业科学进展》等杂志审稿人和珠海市海洋渔业专家库专家。 2018年获“广州市珠江科技新星”称号。2024年入选广东省特支计划青年拔尖人才。

    工作简历:

2002年9月－2006年7月 西南大学  学士

2006年9月－2009年7月 中国海洋大学 硕士

2009年9月－2012年7月 新奥门31999    博士

2012年9月－2016年7月 新奥门31999海洋学院 讲师

2016年7月－2023年6月  新奥门31999新奥门31999 副教授

2023年6月-至今             新奥门31999新奥门31999 教授

科研项目：

  1. 国家自然科学基金面上项目，32473189，神经坏死病毒衣壳蛋白(CP)通过SUMO化修饰途径调控花鲈RLRs信号通路的分子机制，2025/01-2028/12，50万元，主持
  2. 国家自然科学基金面上项目，32173001，神经坏死病毒衣壳蛋白调控花鲈RLRs信号通路抑制干扰素反应的分子机制，2022/01-2025/12，58万元，主持
  3. 国家自然科学基金青年基金，31502195，海鲈RLRs信号通路在鱼类神经坏死病毒感染过程中的作用机制研究，2016/01-2018/12，25.2万元，主持
  4. 国家重点研发计划“典型脆弱生态系统保护与修复”项目，课题三“濒危旗舰水生动物适应机制及关键保护技术研究”，2022/09-2027/09，425万，参与，骨干成员。
  5. 广西壮族自治区自然科学基金（重点项目）， 2021GXNSFDA075015，神经性坏死病毒衣壳蛋白在病毒致病性和种间传播中的作用机制研究、 35万、 2021-04-01至2025-03-31，广东负责人
  6. 珠海市现代农业发展中心黄鳍鲷育种及病害防控技术研究采购项目，2021-10-08至2022-4-8，189.8万元，主持
  7. 广东省科技计划项目，2017A030303010，基于高通量筛选技术的抗鱼类病毒海洋天然化合物筛选，2017/01-2018/12，10万元，主持
  8. 广东省自然科学基金博士启动项目，S2013040016711，斑马鱼精子microRNA表达谱的研究，2013/10 -2015/10，3万元，主持，
  9. 广州市珠江科技新星，201806010047，海鲈RLRs抗病毒信号通路相关miRNA鉴定及调控机制研究，2018/04-2021/03，30万元，主持
  10. 珠海市科技计划项目，2021，鱼类神经坏死病毒衣壳蛋白单克隆抗体对鲈鱼亲本免疫保护的应用研究，2021/5/1-2022/6/30，4万元，主持
  11. 珠海市斗门区农业科技计划项目，2020，鱼类神经坏死病毒衣壳蛋白单克隆抗体对鲈鱼亲本免疫保护的应用研究，2020/11-2021/11，主持
  12. 海鲈SPF（无神经坏死病毒）亲鱼筛选，2020，2020/11-2021/5，16万元，主持
  13. 三沙市海洋保护区管理局，北岛海域海龟饵料资源监测，2023/4-2023/12，34万，主持
  14. 珠海市现代农业发展中心,珠海市现代农业发展中心珠海市种业规划（2023-2027年）服务采购项目,2023/10-2024/5，29.8万，主持
  15. 国家自然科学基金面上项目，31771587，斑马鱼生殖质microRNA miRNA-202调控原始生殖细胞发育的作用机制研究，2018/01-2021/12，72万元，参加
  16. 国家自然科学基金青年基金，31602191，黑鲷JAK-STAT信号通路在鱼类神经坏死病毒感染过程中的作用机制研究，2017/01-2019/12，24万元，参加


教改项目：

  1. 2023 年广东省一流本科课程建设项目（粤教高函〔2023〕33 号），主持
  2. 2022 年广东省高等教育教学研究和改革项目(粤教高函〔2023〕4 号），主持

荣誉和获奖

    广州市珠江科技新星（2018）

    新奥门31999第九届教师教学竞赛理科组一等奖（2021）

    新奥门31999第十一届校级本科教育教学成果奖二等奖（2023）

     广东省特支计划青年拔尖人才（2024）
 

 

第一或通讯作者发表科研论文(#共同第一作者；*共同通讯作者):

2024年

  1. W. Zhang, H. Chen, W. Liu, K. Jia*, M. Yi*, Characterizing Marine Medaka (Oryzias melastigma) Haploid Embryonic Stem Cells: A Valuable Tool for Marine Fish Genetic Research, Animals 14 (2024) 2739. https://doi.org/10.3390/ani14182739.
  2. H. Huang, X. Lu, J. Guo, Y. Chen, M. Yi*, K. Jia*, Protective efficacy and immune responses of largemouth bass (Micropterus salmoides) immunized with an inactivated vaccine against the viral hemorrhagic septicemia virus genotype IVa, Fish & Shellfish Immunology 151 (2024) 109691. https://doi.org/10.1016/j.fsi.2024.109691.
  3. X. Chen, W. Zhang, H. Huang, M. Yi*, K. Jia*, Sea perch (Lateolabrax japonicus) UBC9 augments RGNNV infection by hindering RLRs-interferon response, Fish & Shellfish Immunology 146 (2024) 109408. https://doi.org/10.1016/j.fsi.2024.109408.
       2023年
  4. W. Zhang, L. Yao, L. Chen, P. Jia, Y. Xiang, M. Yi*, K. Jia*, Ring Finger Protein 34 Facilitates Nervous Necrosis Virus Evasion of Antiviral Innate Immunity by Targeting TBK1 and IRF3 for Ubiquitination and Degradation in Teleost Fish, Journal of Virology (2023). https://doi.org/10.1128/jvi.00533-23.
  5. L. Yao, W. Zhang, X. Chen, M. Yi*, K. Jia*, Methyltransferase-like 3 suppresses red spotted grouper nervous necrosis virus and viral hemorrhagic septicemia virus infection by enhancing type I interferon responses in sea perch, Fish & Shellfish Immunology 140 (2023) 108993. https://doi.org/10.1016/j.fsi.2023.108993.
  6. X. Lu, Z. Hu, H. Huang, M. Yi*, K. Jia*, Molecular characterization, transcriptional regulation of sea perch Moloney leukemia virus 10 and its antiviral function against VHSV, Fish & Shellfish Immunology 139 (2023) 108874. https://doi.org/10.1016/j.fsi.2023.108874.

2022年

  1. K. Jia, Y. Peng, X. Chen, H. Jian, M. Jin, Z. Yi, M. Su, X. Dong, M. Yi, A Novel Inovirus reprograms metabolism and motility of marine Alteromonas, Microbiology Spectrum. 0 (2022) e03388-22.
  2. WW. Zhang, JH. Weng, L. Yao, P. Jia, MS. Yi, KT. Jia*, Nectin4 antagonises type I interferon production by targeting TRAF3 for autophagic degradation and disrupting TRAF3-TBK1 complex formation. International Journal of Biological Macromolecules, (2022)，218:654-664
  3. HB. Pan, HQ. Chen, LS. Chen, WW. Zhang, P. Lan, P. Jia, SZ. Li, M.S Yi, KT. Jia*, Establishment and characterization of a liver cell line from black porgy, Acanthopagrus schlegelii, Aquaculture Reports. 25 (2022) 101213.
  4. P. Jia, WW. Zhang, YX. Xiang, Xb. Lu, XQ. Chen, HB. Pan, MS. Yi, KT. Jia*, The capsid protein of nervous necrosis virus antagonizes host type I IFN production by a dual strategy to negatively regulate retinoic acid-inducible gene-I-like receptor pathways, Journal of Immunology. (2022) 12.
  5. XQ. Chen, WW. Zhang, Z. Hu, KP. Cui, MS. Yi, KT. Jia*, Sea perch (Lateolabrax japonicus) autophagy related gene 5 promotes RGNNV infection via inhibiting RLRs-interferon signaling pathway, Fish & Shellfish Immun. 127 (2022) 910–917.
  6. P. Jia, LR. Lin, L. Xu, MS. Yi, KT. Jia *. Establishment and characterization of a fin cell line derived from the Atlantic salmon salmo salar and its application to fish virology study, J. Ocean Univ. China. (2022).
  7. Lu, X.; Li, W.; Guo, J.; Jia, P.; Zhang, W.; Yi, M*, K. Jia*. N protein of viral hemorrhagic septicemia virus suppresses STAT1-mediated MHC class II transcription to impair antigen presentation in sea perch, Lateolabrax japonicus. Journal of Immunology (0022-1767),(2022),2100939,
  8. Zhang, W.; Yao, L.; Chen, X.; Li, M.; Yi, M.*; Jia, K*. Functional characterization of myosin III light chain b of sea perch (Lateolabrax japonicus) in response to fish virus infection. Aquaculture 2022, 550, 737840, doi:10.1016/j.aquaculture.2021.737840.
  9.  Zhang, W.-W.; Jia, P.; Lu, X.-B.; Chen, X.-Q.; Weng, J.-H.; Jia, K.T*.; Yi, M.-S*. Capsid protein from red-spotted grouper nervous necrosis virus induces incomplete autophagy by inactivating the HSP90ab1-AKT-MTOR pathway. Zoological Research 2022, 43, 98–110, doi:10.24272/j.issn.2095-8137.2021.249.
  10. Jia, P.; Jin, F.; Xiang, Y.; Li, J.; Pan, H.; Cui, K.; Yi, M.; Jia, K*. Establishment and characterization of a fin cell line from yellowfin sea bream (Acanthopagrus latus) and its application to fish virology and toxicology. Aquaculture 2022, 549, 737801, doi:10.1016/j.aquaculture.2021.737801.

  2021年

  1. Zhang, W.; Chen, X.; Yu, F.; Li, F.; Li, W.; Yi, M.*; Jia, K*. α-lipoic acid exerts its antiviral effect against viral hemorrhagic septicemia virus (VHSV) by promoting upregulation of antiviral genes and suppressing VHSV-induced oxidative stress. Virol. Sin. 2021, doi:10.1007/s12250-021-00440-5.
  2. Li, Y.; Jia, P.; Yu, F.; Li, W.; Mao, C.; Yi, M.; Gu, Q*.; Jia, K*. Establishment and characterization of a liver cell line, all, derived from yellowfin sea bream, Acanthopagrus latus, and its application to fish virology. J Fish Dis 2021, doi:10.1111/jfd.13543.
  3. Jia P, Pan H, Cui K, Jia, K.*, Yi M*. MicroRNA expression profiling of sea perch brain cells reveals the roles of microRNAs in autophagy induced by RGNNV infection. J Fish Dis (2021) doi:10.1111/jfd.13389
  4. Lu X, Zeng J, Jia K*, Yi M*. Antiviral activities of sea perch type I and type II IFNs against RGNNV and their different roles in antigen presentation. Aquaculture (2021) 534:736314. doi:10.1016/j.aquaculture.2020.736314
  5. Xiang Y, Zhang W, Jia P, Lu X, Liu W, Yi M*, Jia K*. E3 ubiquitin ligase RNF114 inhibits innate immune response to red-spotted grouper nervous necrosis virus infection in sea perch by targeting MAVS and TRAF3 to mediate their degradation. Journal of Immunology (2021)ji2000083. doi:10.4049/jimmunol.2000083

   2020年

  1. Zhang, W.; Jia, K.*; Jia, P.; Xiang, Y.; Lu, X.; Liu, W.; Yi, M.*Marine medaka heat shock protein 90ab1 is a receptor for red-spotted grouper nervous necrosis virus and promotes virus internalization through clathrin-mediated endocytosis. PLOS Pathogens, 2020,16, e1008668, doi:10.1371/journal.ppat.1008668.
  2. Liu, W.; Jin, Y.; Zhang, W.; Xiang, Y.; Jia, P.; Yi, M.; Jia, K. MiR-202-5p inhibits RIG-I-dependent innate immune responses to RGNNV infection by targeting TRIM25 to mediate RIG-I ubiquitination. Viruses 2020, 13.
  3. Jia, P.; Zhang, W.; Xiang, Y.; Lu, X.; Liu, W.; Jia, K.*; Yi, M*. Ubiquitin-specific protease 5 was involved in the interferon response to RGNNV in sea perch (Lateolabrax japonicus). Fish & Shellfish Immunology 2020, 103, 239–247, doi:10.1016/j.fsi.2020.04.065.
  4. Jia, P.; Chen, X.; Fu, J.; Yi, M.; Chen, W.; Jia, K.* Near-complete genome sequence of a fish nervous necrosis virus isolated from hybrid grouper in china. Microbiol Resour Announc 2020, 9, e01453-19, /mra/9/15/MRA.01453-19.atom, doi:10.1128/MRA.01453-19.

   2019年

  1. Zhang, W.; Li, Z.; Xiang, Y.; Jia, P.; Liu, W.; Yi, M.*; Jia, K.* Isolation and identification of a viral haemorrhagic septicaemia virus (VHSV) isolate from wild largemouth bass Micropterus salmoides in China. Journal of Fish Diseases 2019, 42, 1563–1572, doi:10.1111/jfd.13078.
  2. Zhang, W.; Jia, P.; Liu, W.; Jia, K.*; Yi, M*. Screening for antiviral medaka haploid embryonic stem cells by genome wide mutagenesis. Marine Biotechnology, 2019, doi:10.1007/s10126-018-09870-x.
  3. Xiang, Y.; Jia, P.; Liu, W.; Yi, M.*; Jia, K.*Comparative transcriptome analysis reveals the role of p53 signalling pathway during red-spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells. Journal of Fish Diseases 2019, 42, 585–595, doi:10.1111/jfd.12960.
  4. Li, J.; Jia, P.; Chen, X.; Lai, M.; Jin, F.; Liu, W.; Yi, M. Jia, K. Establishment and characterization of a fin tissue cell line derived from silver pomfret, Pampus argenteus. Journal of Fish Diseases, 2019, 42, 1391–1399, doi:10.1111/jfd.13059.
  5. Jin, Y.; Liu, W.; Xiang, Y.; Zhang, W.; Zhang, H.; Jia, K.*; Yi, M*. Maternal miR-202-5p is required for zebrafish primordial germ cell migration by protecting small GTPase Cdc42. J Mol Cell Biol, 2019, doi:10.1093/jmcb/mjz103.
  6. Jin, Y.#; Jia, K.#,*; Zhang, W.; Xiang, Y.; Jia P.; Liu, W.; Yi, M*.Zebrafish TRIM25 promotes innate immune response to RGNNV infection by targeting 2CARD and RD regions of RIG-I for K63-linked ubiquitination. Frontiers in Immunology, 2019, 10, 12.
  7. Jia, K.#; Bian, C.#; Yi, Y.;#Li, Y.; Jia, P.; Gui, D.; Zhang, X.; Lin, W.; Sun, X.; Lv, Y.; et al. Whole genome sequencing of chinese white dolphin (Sousa chinensis) for high-throughput screening of antihypertensive peptides. Marine. Drugs, 2019, 16.
  8. Xiang, Y., P. Jia, W. Liu, M. Yi*, K. Jia*. Comparative transcriptome analysis reveals the role of p53 signalling pathway during red-spotted grouper nervous necrosis virus infection in Lateolabrax japonicus brain cells. Journal of Fish Diseases 42 (2019): 585–595.

   2018年

  1. W. Zhang, P. Jia, W. Liu, Y. Li, M. Yi*, K. Jia*, Functional characterization of tumor necrosis factor receptor associated factor 3 of sea perch (Lateolabrax japonicas) in innate immune, Fish Shellfish Immunol. 75 (2018) 1–7.doi:10.1016/j.fsi.2018.01.039.
  2. K. Jia#, Y. Yuan#, W. Liu, L. Liu, Q. Qin, M. Yi*, Identification of inhibitory compounds against singapore grouper iridovirus infection by cell viability based screening assay and droplet digital PCR, Mar. Biotechnol. 20 (2018) 35–44. doi:10.1007/s10126-017-9785-1.
    1. 2017年
  3. Y. Xiang, W. Liu, P. Jia, Y. Li, Y. Jin, L. Chen, J. Zhang, K. Jia*, M. Yi*, Molecular characterization and expression analysis of interferon-gamma in black seabream Acanthopagrus schlegelii, Fish & Shellfish Immunology, 70 (2017)140–148.
  4. Y. Le, P. Jia, Y. Jin, W. Liu, K. Jia*, M. Yi*, The antiviral role of heat shock protein 27 against red spotted grouper nervous necrosis virus infection in seaperch, Fish & Shellfish Immunology, 70 (2017) 185–194.
  5. Y.L. Jin, L.M. Chen, Y. Le, Y.L. Li, Y.H. Hong, K.T. Jia*, M.S. Yi*, Establishment of a cell line with high transfection efficiency from zebrafish Danio rerio embryos and its susceptibility to fish viruses, J. Fish Biol. 91 (2017) 1018–1031. doi:10.1111/jfb.13387.
  6. P. Jia, W. Liu, L. Chen, Y. Jin, J. Zhang, K. Jia*, M. Yi*, Identification of sea perch (Lateolabrax japonicus) ribonucleoprotein PTB Binding 1 involved in antiviral immune response against RGNNV, Fish Shellfish Immunol. 60 (2017) 119–128.doi:10.1016/j.fsi.2016.11.047.
  7. J. Zhang, W. Liu, Y. Jin, P. Jia, K. Jia*, M. Yi*, MiR-202-5p is a novel germplasm-specific microRNA in zebrafish, Sci. Rep. 7 (2017) 7055.doi:10.1038/s41598-017-07675-x.
  8. Y. Le, Y. Li, Y. Jin, P. Jia, K. Jia*, M. Yi*, Establishment and characterization of a brain cell line from sea perch, Lateolabrax japonicus, Vitr. Cell. Dev.Biol. - Anim. 53 (2017) 834–840. doi:10.1007/s11626-017-0185-7.
    1. 2016年
  9. P. Jia, K. Jia#, L. Chen, Y. Le, Y. Jin, J. Zhang, L. Zhu, L. Zhang*, M. Yi*, Identification and characterization of the melanoma differentiation-associated gene 5 in sea perch, Lateolabrax japonicus, Dev.Comp. Immunol. 61 (2016) 161–168. doi:10.1016/j.dci.2016.03.029.
  10. P. Jia, Y. Jin, L. Chen, J. Zhang, K. Jia*, M. Yi*, Molecular characterization and expression analysis of mitochondrial antiviral signaling protein gene in seaperch, Lateolabrax japonicus, Dev. Comp. Immunol. 55 (2016) 188–193.doi:10.1016/j.dci.2015.10.014.
    1. 2015年
  11. K. Jia, L. Ding, L. Zhang, M. Zhang, M. Yi, Y. Wu, In vitro assessment of environmental stress of persistent organic pollutants on the Indo-Pacific humpback dolphin, Toxicol. Vitr. 30 (2015) 529-535. doi:10.1016/j.tiv.2015.09.008.
  12. Jia, P., Zhang. J., Jin, Y., Zeng, L., Jia, K.*, Yi, M*. Characterization and expression analysis of laboratory of genetics and physiology 2 gene in sea perch, Lateolabrax japonicus, Fish Shellfish Immunol. 47 (2015) 214–220.doi:10.1016/j.fsi.2015.09.004.
  13. P. Jia, K. Jia*, M. Yi*, Complete genome sequence of a fish nervous necrosis virus isolated from sea perch (Lateolabrax japonicus) in China, Genome Announc. 3(2015) e00048-15. doi:10.1128/genomeA.00048-15.
  14. K.T. Jia#, J. Zhang#, P. Jia, L. Zeng, Y. Jin, Y. Yuan, J. Chen, Y. Hong, M. Yi, Identification of microRNAs in zebrafish spermatozoa, Zebrafish. 12 (2015) 387–397. doi:10.1089/zeb.2015.1115.
    1. 2014年
  15. K. Jia, W. Lin, D. Gui, L. Karczmarski, Y. Wu, Molecular evidence reveals the distinctiveness of indopacific finless porpoises (Neophocaena phocaenoides) in the pearl river estuary and insights into genus neophocaenas origin, Mar. Biol.161 (2014) 1919–1930.
    1. 2013年
  16. Jia, K.; Wu, Y.; Liu, Z.; Mi, S.; Zheng, Y.; He, J.; Weng, S.; He, J.; Guo, C. Mandarin fish caveolin 1 interaction with major capsid protein of infectious spleen and kidney necrosis virus and its role in early stages of infection., J. Virol. 87 (2013) 3027–38. doi:10.1128/JVI.00552-12.
  17. K. Jia, Z. Liu, C. Guo, Q. Xia, S. Mi, X.D. Li, S. Weng, J. He, The potential role of microfilaments in host cells for infection with infectious spleen and kidney necrosis virus infection, Virol. J. 10 (2013) 77. doi:10.1186/1743-422X-10-77.
  18. D.Gui#, K. Jia#. Xia, L.Yang, J. Chen, Y. Wu, M. Yi, De novo assembly of the indo Pacific humpback dolphin leucocyte transcriptome to identify putative genes involved in the aquatic adaptation and immune response, PLoS One. 8 (2013).
  19. 贾坤同,梁玉波,宋晓玲,杨冰,刘莉,樊景凤,孔晓瑜,史成银,黄健＊,海水养殖鱼类中虹彩病毒无症状感染的套式PCR分析，中国水产科学，16(5)：758-764, 2009.
  20. 贾坤同,孔晓瑜,史成银＊,鱼类细胞肿大病毒属全基因组结构和蛋白功能研究进，动物医学进展, 30(2):86-89, 2009

第一或通讯作者发表教改论文(#共同第一作者；*共同通讯作者):

  1. 贾坤同*,李俊,米舒,宁曦,孟峥,苏明,易梅生,“海洋微生物学实验” 课程思政探索和实践， 微生物学通报，2021，49（1），383-391
  2. 贾坤同*,李春荣,宁曦,等.“海洋微生物学”一流本科课程教学改革与实践.微生物学通报,1-13[2024-12-01].https://doi.org/10.13344/j.microbiol.china.240694.