一、简历
何键，新奥门31999新奥门31999副教授，本科毕业于吉林大学，博士毕业于新奥门31999，2016-2022年在新奥门31999新奥门31999任职特聘副研究员，2022年7月-至今，为新奥门31999新奥门31999副教授。主要聚焦于海洋生物低氧环境适应性开展研究，在深海生物低氧适应性机制、低氧胁迫与鱼类传染性疾病的爆发等方面取得了系列研究进展。
二、主持及参加科研项目
1. 国家自然科学基金青年项目（31702381），虹彩病毒ISKNV利用HIF-1信号通路调控宿主糖代谢，2018.01-2020.12，主持。
2. 广东省基础与应用基础研究基金自然科学基金项目-面上项目（2021A1515010647），鳜FIH调控NF-κB 信号通路的分子，2021.01-2023.12，主持。
3. 广州市科技计划项目基础与应用基础研究项目（202102020299），低氧胁迫促进传染性脾肾坏死病毒病爆发及其机制研究，2021.04-2023.03，主持。
4. 高校基本科研业务费青年教师培育项目（20lgpy53），ISKNV VP77R调控宿主低氧应激信号通路，2020.01-2022.12，主持。
5. 国家重点研发“蓝色粮仓”（2018YFDD0900504），病原-宿主互作失衡与疫病发生机制， 2018.12-2022.12，参与。
6. 广东省重点领域研发计划项目（2019B020217001）, 水产重要疫病智能诊断和预警技术的研究与示范， 2019.01-2021.12，参与。
7. 广州市科学研究计划重点项目（201904020043），鱼类疫苗浸泡免疫机制及应用， 2019.4-2022.3，参与。
三、论文发表
1. Jian He, Yi Wen Zheng, Yi Fan Lin, Su Mi, Xiao Wei Qin, Shao Ping Weng, Jian Guo He, Chang Jun Guo. Caveolae Restrict Tiger Frog Virus Release in HepG2 cells and Caveolae-Associated Proteins Incorporated into Virus Particles. Sci Rep. 2016 Feb 18; 6:21663.
2. Chang-Jun Guo #, Jian He #, Jian-Guo He. The immune evasion strategies of fish viruses. Fish and Shellfish Immunology. 2019 Mar, 86:772-784. doi: 10.1016/j.fsi.2018.12.013.
3. Jian He, Shu Mi, Xiao-Wei Qin, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo He. Tiger frog virus ORF104R interacts with cellular VDAC2 to inhibit cell apoptosis. Fish and Shellfish Immunology. doi.org/10.1016/j.fsi.2019.07.017.
4. Jian He, Yang Yu, Xiao-Wei Qin, Ruo-Yun Zeng, Yuan-Yuan Wang, Zhi-Min Li, Shu Mi, Shao-Ping Weng, Chang-Jun Guo, Jian-Guo He. Identification and functional analysis of the mandarin fish (Siniperca chuatsi) hypoxia-inducible factor-1α involved in the immune response. Fish and Shellfish Immunology.doi.org/10.1016/j.fsi.2019.04.298.
5. Jian He, Tao-Lin Xie, Xiao Li, Yang Yu, Zhi-Peng Zhan, Shao-Ping Weng, Jian-Guo He, Chang-Jun Guo. Molecular cloning of Y-Box binding protein-1 from mandarin fish and its roles in stress-response and antiviral immunity. Fish and Shellfish Immunology. 2019 Jul 29;93:406-415. doi: 10.1016/j.fsi.2019.07.069.
6. Yi-Fan Lin #, Jian He #, Ruo-Yun Zeng, Zhi-Min Lia, Zhi-Yong Luo, Wei-Qiang Pan, Shao-Ping Weng, Chang-Jun Guoa∗, Jian-Guo He. Deletion of the Infectious spleen and kidney necrosis virus ORF069L reduces virulence to mandarin fish Siniperca chuatsi. Fish and Shellfish Immunology.2019. 95: 328–335.
7. Jian He, Nan-Nan Chen, Zhi-Min Li, Yuan-Yuan Wang, Shao-Ping Weng, Chang-Jun Guo*and Jian-Guo He. Evidence for a Novel Antiviral Mechanism of Teleost Fish: Serum-Derived Exosomes Inhibit Virus Replication through Incorporating Mx1 Protein. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2021. 22, 10346.
8. Long Zhang#, Jian He #, Peipei Tan, Zhen Gong, Shiyu Qian, Yuanyuan Miao, Han-Yu Zhang, Guangxian Tu, Qi Chen, Qiqi Zhong, Guanzhu Han, Jianguo He*, Muhua Wang*. The genome of an apodid holothuroid (Chiridota heheva) provides insights into its adaptation to a deep-sea reducing environment. Communications Biology. 2022.
9. Jian He, Yang Yu, Zhi-Min Li, Zhi-Xuan Liu, Shao-Ping Weng, Jian-Guo He*, Chang-Jun Guo*. Hypoxia triggers the outbreak of infectious spleen and kidney necrosis virus disease through viral hypoxia response elements. Virulence (ISSN: 2150-5594). 2022; DOI：10.1080/21505594.2022.2065950.
10. Xiao-Wei Qin, Jian He, Yang Yu, Chang Liu, Zhi-Yong Luo, Zhi-Min Li, Shao-Ping, Weng, Chang-Jun Guo*, Jian-Guo He. The roles of mandarin fish STING in innate immune defense against infectious spleen and kidney necrosis virus infections. Fish and Shellfish Immunology, 2020, 100:80-89.
11. Chang Liu, Xiao-Wei Qin, Jian He, Shao-Ping Weng, Jian-Guo He, Chang-Jun Guo*. Roles of extracellular matrix components in Tiger frog virus attachment to fathead minnow (Pimephales promelas) cells. Fish and Shellfish Immunology, 2020, 107: 9–15.
12. Yu-Xin Ye, Jinhui Pan , Yong Shen, Minhui Shen, Huijie Yan, Jian He, Xin Yang, Fang Zhu, Jianqiao Xu , Jianguo He, and Gangfeng Ouyang *. A solar-to-chemical conversion efficiency up to 0.26% achieved in ambient conditions. PNAS 2021, Vol. 118 No. 46 e2115666118.
13. Ruoyun Zeng, Weiqiang Pan, Yifan Lin, Jian He, Zhiyong Luo, Zhimin Li, Shaoping Weng, Jianguo He *, and Changjun Guo *. Development of a gene-deleted live attenuated candidate vaccine against fish virus (ISKNV) with low pathogenicity and high protection.2021, iScience.24, 102750.
14. Yuan-yuan Wang #, Ling-bo Ma #, Jian He, Zixuan Liu, Shao-ping Weng, Lu-min Wang, Jian-guo He, Chang-jun Guo*. Whole genome sequencing and comparative genomic analyses of Planococcus alpniumensis MSAK28401 T, a new species isolated from Antarctic krill. BMC Microbiol. 2021, 21(1):288.
15. Yuanyuan Wang, Lingbo M, Jian He, Zhili He, Muhua Wang, Zixuan Liu, Zhimin Li, Lumin Wang, Shaoping Weng, Changjun Guo,*, Jianguo He *. Environmental risk characteristics of bacterial antibiotic resistome in Antarctic krill. Ecotoxicology and Environmental Safety, 2022, 232: 113289.
16. Huijie Yan, Minhui Shen, Yong Shen, Xu-Dong Wang, Wei Lin, Jinhui Pan , Jian He, Yu-Xin Ye,1 Xin Yang, Fang Zhua , Jianqiao Xu , Jianguo He, and Gangfeng Ouyang *. Spontaneous exciton dissociation in organic photocatalyst under ambient conditions for highly efficient synthesis of hydrogen peroxide. PNAS 2022, Vol. 119 No. 22 e2202913119.
